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SHARPIN Mouse anti-Human, Clone: OTI1F4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527500
DescriptionComponent of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Sharpin; Shank-associated RH domain-interacting protein; Shank-interacting protein-like 1; hSIPL1; SHARPIN; SIPL1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Human recombit protein fragment corresponding to amino acids 1-326 of SHARPIN produced in E.coli|
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