DescriptionSHBG is a steroid binding protein that was first described as a plasma protein secreted by the liver and is thought to participate in the regulation of steroid responses. SHBG transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Low plasma SHBG levels are associated with obesity, abdominal adiposity, metabolic syndrome, and predict the development of type 2 diabetes. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus.
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|Antigen Affinity Chromatography|