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SHC Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

$395.30

Specifications

Antigen SHC
Concentration 0.31 mg/mL
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Conjugate Unconjugated
Format Liquid
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Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-172-5990
Encompass_Preferred
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Proteintech Group IncSupplier Diversity Partner
100541AP150UL
150 μL
Each for $395.30
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Description

Description

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p47Shc and isoform p52Shc, once phosphorylated, couple activated receptor kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p47Shc and isoform p52 may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.
Specifications

Specifications

SHC
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Polyclonal
-20°C
0.31 mg/mL
Unconjugated
Rabbit
Human, Mouse
IgG
Antigen Affinity Chromatography
Antibody
SDS
Product Certifications
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