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SHC Mouse anti-Human, Clone: OTI3A1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525076

Catalog No. PIMA525076


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Description

Description

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
Specifications

Specifications

SHC
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P29353
SHC, SHCA, SH2 domain protein C1, SHC (Src homology 2 domain-containing) transforming protein 1, SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
6464
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
OTI3A1
Unconjugated
SHC1
Liquid
SHC1
Full length human recombit protein of SHC1 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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