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SHMT2 Mouse anti-Human, Clone: OTI1E12, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527057

Catalog No. PIMA527057


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Description

Description

Mammalian serine hydroxymethyltransferase (SHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate in the cytoplasm (cSHMT, SHMT1) and mitochondria (mSHMT, SHMT2). cSHMT preferentially supplies one-carbon units for thymidylate biosynthesis, depletes methylenetetrahydrofolate pools for S-adenosylmethionine (SAM) synthesis by synthesizing serine, sequesters 5-methyltetrahydrofolate, and inhibits SAM synthesis.
Specifications

Specifications

SHMT2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P34897
GLYA, SHMT, GLY A+, glycine auxotroph A, human complement for hamster, glycine hydroxymethyltransferase, serine aldolase, serine hydroxymethylase, serine hydroxymethyltransferase, mitochondrial, serine methylase, threonine aldolase
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
6472
Immunohistochemistry (Paraffin), Western Blot
OTI1E12
Unconjugated
SHMT2
Liquid
SHMT2
Full length human recombit protein of SHMT2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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