Tocris™ SIB 1893

mGlu5 antagonist and positive allosteric modulator at mGlu4

Manufacturer: Tocris™ 1214/10

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Catalog No. 12-141-0

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For Research Use Only


    Product Type SIB 1893
    Inhibitors SIB 1893
    Molecular Weight 195.26
    Quantity 10mg

    A highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype; displays an IC50 value of 0.3µM at hmGlu5, compared with > 100µM at hmGlu1b, hmGlu2, hmGlu6, hmGlu7 and hmGlu8. Centrally active upon systemic administration in vivo. Positive allosteric modulator at mGlu4 receptors.

    • Chemical Name: 2-Methyl-6-(2-phenylethenyl)pyridine
    • Formula: C14H13N
    • CAS Number: 6266-99-5
    • Solubility: Soluble to 100mM in DMSO

  • Description & Specifications

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