Tocris SIB 1893
mGlu5 antagonist and positive allosteric modulator at mGlu4
Manufacturer: Tocris 1214/10
DescriptionA highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype; displays an IC50 value of 0.3µM at hmGlu5, compared with > 100µM at hmGlu1b, hmGlu2, hmGlu6, hmGlu7 and hmGlu8. Centrally active upon systemic administration in vivo. Positive allosteric modulator at mGlu4 receptors.
- Chemical Name: 2-Methyl-6-(2-phenylethenyl)pyridine
- Formula: C14H13N
- CAS Number: 6266-99-5
- Solubility: Soluble to 100mM in DMSO
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