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Tocris™ SIB 1893

mGlu5 antagonist and positive allosteric modulator at mGlu4

Manufacturer:  Tocris™ 1214/50

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Catalog No. 12-145-0R

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For Research Use Only



A highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype; displays an IC50 value of 0.3µM at hmGlu5, compared with > 100µM at hmGlu1b, hmGlu2, hmGlu6, hmGlu7 and hmGlu8. Centrally active upon systemic administration in vivo. Positive allosteric modulator at mGlu4 receptors.
  • Chemical Name: 2-Methyl-6-(2-phenylethenyl)pyridine
  • Formula: C14H13N
  • CAS Number: 6266-99-5
  • Solubility: Soluble to 100mM in DMSO
Description & Specifications


SIB 1893
SIB 1893
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