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Siglec-3/CD33 Antibody (WM53), Novus Biologicals™
Mouse Monoclonal Antibody has been used in 1 publication
Supplier: Novus Biologicals NBP2329310.2MG
Description
Siglec-3/CD33 Monoclonal antibody specifically detects Antigen in Human samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry (Frozen).Specifications
Siglec-3/CD33 | |
Monoclonal | |
Unconjugated | |
PBS with 0.05% BSA. with 0.05% Sodium Azide | |
CD33 antigen, CD33 antigen (gp67), CD33 molecule, FLJ00391, myeloid cell surface antigen CD33, p67, sialic acid binding Ig-like lectin 3, Sialic acid-binding Ig-like lectin 3, SIGLEC-3, SIGLEC3gp67 | |
Mouse | |
67 kDa | |
0.2 mg | |
Immunology | |
945 | |
Human | |
Purified |
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen) | |
WM53 | |
Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunohistochemistry-Frozen 0.5-1ug/ml | |
P20138 | |
CD33 | |
Human AML cells | |
Protein A purified | |
RUO | |
Primary | |
Recognizes a 67kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immuno-receptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells. | |
Store at 4C. | |
IgG1 κ |
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