Sino Biological™ CD19 Recombinant Human Protein, His Tag Non-distribution product as customer accommodation.

This recombinant protein is expressed from a DNA sequence encoding the extracellular domain (Met 1-Lys 291) of human CD19 (AAB60697) fused to a polyhistidine tag at the C-terminus

Manufacturer: Invitrogen 11880H08H250

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Catalog No. 11-880-H08HL

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For Research Use Only. Not for use in diagnostic procedures.


    For Use With (Application) Proteins, Expression, Isolation & Analysis; Enzyme & Protein Activity Assays; Protein Assay Controls, Reference Standards & Accessories
    Format Lyophilized
    Gene ID (Entrez) 930
    Molecular Weight 31.6kDa
    Purity ≥90% by SDS-PAGE
    Quantity 5 x 50μg
    Storage Requirements Store at -20° to -70°C. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles. Expires one year from date of receipt when stored as instructed.
    Structural Form Truncated/Recombinant/Cell Surface Protein
    Protein Subtype Other Proteins
    Endotoxin Concentration <1 EU/μg
    Gene Alias B4, mgC12802
    Common Name CD19 molecule
    Gene Symbol CD19
    Protein Tag His Tag
    Validated Application Assay Standard
    Protein Family CD Proteins
    Expression System Mammalian

    Cluster of Differentiation 19 (CD19) recombinant human protein is supplied as a lyophilized powder. This protein is suitable for use in analysis of protein structure the study of protein-protein interactions, and cell biology research applications. It can also be used as an immunogen, or as a protein standard.Background: Cluster of Differentiation 19 (CD19), is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulinlike) domains. CD19 forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. It interacts with VAV. It interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. CD19 also interacts with PLCG2 when phosphorylated on Tyr-409. CD19 is an important pan B cell marker and co-stimulatory protein in humans and mice. CD19 is a hallmark differentiation antigen of the B cell lineage and positively regulates antigen receptor signal transduction in mature B cells. CD19 defines signaling thresholds for the Ag receptor as well as other cell surface receptors that regulate B lymphocyte selection, activation, and differentiation. Defects in CD19 are a cause of hypogammaglobulinemia.

    • N-terminal Sequence Analysis: Pro 20
    • Activity: Measured by its binding ability in a functional ELISA; immobilized human CD19 at 2µg/mL (100µL/well) has been shown to bind biotinylated human CD9 with a linear range of 0.032-0.8µg/mL
    • Formulation: lyophilized in PBS, pH 7.4, 5% mannitol, 5% trehalose, and 0.02% Tween®-80
    • Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2mg/mL or lower; aliquot and use as soon as possible

    Shipping Condition: Room Temperature. Manufactured by Sino Biological (China).

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