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Sino Biological™ CD19 Recombinant Human Protein, His Tag Non-distribution product as customer accommodation.

This recombinant protein is expressed from a DNA sequence encoding the extracellular domain (Met 1-Lys 291) of human CD19 (AAB60697) fused to a polyhistidine tag at the C-terminus

Manufacturer:  Invitrogen 11880H08H50

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Catalog No. 11-880-H08H50


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Disclaimers:

For Research Use Only. Not for use in diagnostic procedures.


Specifications

Description

Cluster of Differentiation 19 (CD19) recombinant human protein is supplied as a lyophilized powder. This protein is suitable for use in analysis of protein structure the study of protein-protein interactions, and cell biology research applications. It can also be used as an immunogen, or as a protein standard.Background: Cluster of Differentiation 19 (CD19), is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulinlike) domains. CD19 forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. It interacts with VAV. It interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. CD19 also interacts with PLCG2 when phosphorylated on Tyr-409. CD19 is an important pan B cell marker and co-stimulatory protein in humans and mice. CD19 is a hallmark differentiation antigen of the B cell lineage and positively regulates antigen receptor signal transduction in mature B cells. CD19 defines signaling thresholds for the Ag receptor as well as other cell surface receptors that regulate B lymphocyte selection, activation, and differentiation. Defects in CD19 are a cause of hypogammaglobulinemia.
  • N-terminal Sequence Analysis: Pro 20
  • Activity: Measured by its binding ability in a functional ELISA; immobilized human CD19 at 2µg/mL (100µL/well) has been shown to bind biotinylated human CD9 with a linear range of 0.032-0.8µg/mL
  • Formulation: lyophilized in PBS, pH 7.4, 5% mannitol, 5% trehalose, and 0.02% Tween®-80
  • Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2mg/mL or lower; aliquot and use as soon as possible
Description & Specifications

Specifications

Proteins, Expression, Isolation & Analysis; Enzyme & Protein Activity Assays; Protein Assay Controls, Reference Standards & Accessories
930
≥90% by SDS-PAGE
Store at -20° to -70°C. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles. Expires one year from date of receipt when stored as instructed.
Other Proteins
B4, mgC12802
CD19
CD Proteins
His Tag
Lyophilized
31.6kDa
50μg
Truncated/Recombinant/Cell Surface Protein
<1 EU/μg
CD19 molecule
Assay Standard
Mammalian
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