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SIP1 Mouse anti-Human, Clone: 6E5, Active Motif™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$135.30 - $534.00

Specifications

Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Antigen SIP1
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-3138 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
61096
10 μg
Each for $135.30
Add to cart
 
50-199-3137 Non-distribution product as customer accommodation.
View Documents
Active MotifSupplier Diversity Partner
61095
100 μg
Each for $534.00
Add to cart
 
Description

Description

ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.
Specifications

Specifications

Monoclonal
Primary
SIP1
Unconjugated
SDS
Product Certifications
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