SIPA1L1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 250861AP
DescriptionSignal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|E6 targeted protein 1, E6TP1, KIAA0440, SIPA1 like protein 1, SIPA1L1|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|SIPA1L1 Fusion Protein Ag18900|
|Antigen Affinity Chromatography|
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