SIRT1 Monoclonal Antibody (2G1/F7), Active Motif™

Mouse Monoclonal Antibody

Supplier:  Active Motif 39354

Catalog No. 50-199-2687

Description

NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).

Specifications

• Antigen: SIRT1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: 10mM sodium phosphate with 150mM NaCl, 30% glycerol and 0.035% sodium azide; pH 7.5
• Gene Accession No.: Q96EB6
• Gene Symbols: SIRT1
• Immunogen: This SIRT1 antibody was raised against a synthetic peptide corresponding to amino acids 581-630 of human SIRT1.
• Quantity: 10 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: 2G1/F7
• Conjugate: Unconjugated
• Gene: SIRT1
• Gene Alias: 75SirT1; AA673258; hSIR2; hSIRT1; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; RP11-57G10.3; Sir2; Sir2a; SIR2alpha; Sir2l1; sir2-like 1; SIR2-like protein 1; SIRT1; SirtT1 75 kDa fragment; sirtuin 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin type 1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 23411
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid