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SIRT1 Monoclonal Antibody (2G1/F7), Active Motif™
Mouse Monoclonal Antibody
$147.50 - $565.00
Specifications
| Antigen | SIRT1 |
|---|---|
| Clone | 2G1/F7 |
| Concentration | 1 mg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-199-2687
|
Active Motif
39354 |
10 μg |
Each for $147.50
|
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50-199-2686
|
Active Motif
39353 |
200 μg |
Each for $565.00
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Description
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).Specifications
| SIRT1 | |
| 1 mg/mL | |
| Monoclonal | |
| Liquid | |
| RUO | |
| 10mM sodium phosphate with 150mM NaCl, 30% glycerol and 0.035% sodium azide; pH 7.5 | |
| 75SirT1; AA673258; hSIR2; hSIRT1; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; RP11-57G10.3; Sir2; Sir2a; SIR2alpha; Sir2l1; sir2-like 1; SIR2-like protein 1; SIRT1; SirtT1 75 kDa fragment; sirtuin 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin type 1 | |
| SIRT1 | |
| IgG1 | |
| Protein G | |
| Antibody |
| 2G1/F7 | |
| Western Blot | |
| Unconjugated | |
| Mouse | |
| Human | |
| Q96EB6 | |
| 23411 | |
| This SIRT1 antibody was raised against a synthetic peptide corresponding to amino acids 581-630 of human SIRT1. | |
| Primary | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| SIRT1 |
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