Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

SIRT1 Mouse anti-Human, Clone: OTI1H1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527216

Catalog No. PIMA527216


Add to cart

Description

Description

NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metobolism, apoptosis, and authopahy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5 ft.-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
Specifications

Specifications

SIRT1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q96EB6
NAD-dependent deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; SIR2-like protein 1; SIR2alpha; hSIR2; hSIRT1; sir2-like 1; sirtuin type 1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
23411
Western Blot
OTI1H1
Unconjugated
SIRT1
Liquid
SIRT1
Human recombit protein fragment corresponding to amino acids 552-676 of SIRT1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit