SIRT1 Mouse anti-Human, Clone: OTI5B2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527217
DescriptionNAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metobolism, apoptosis, and authopahy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5 ft.-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|NAD-dependent deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; SIR2-like protein 1; SIR2alpha; hSIR2; hSIRT1; sir2-like 1; sirtuin type 1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 552-676 of SIRT1 produced in E.coli|
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