SIRT2 Monoclonal Antibody (7G5), Active Motif™

Rat Monoclonal Antibody

Supplier:  Active Motif 61365

Catalog No. 50-199-3348

Description

The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair. It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells. SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise. SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis.

Specifications

• Antigen: SIRT2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
• Gene Accession No.: Q8IXJ6
• Gene Symbols: SIRT2
• Immunogen: This antibody was raised against a synthetic peptide corresponding to human SIRT2 surrounding serine 331. This antibody recognizes both the unphosporylated and the Ser-331 phosphorylated form of SIRT2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Western Blot
• Clone: 7G5
• Conjugate: Unconjugated
• Gene: SIRT2
• Gene Alias: 5730427M03Rik; 5E5 antigen; mSIR2L2; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; Regulatory protein SIR2 homolog 2; silent information regulator 2; silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2; SIR2; SIR2L; SIR2L2; SIR2-like protein 2; sir2-related protein type 2; SIRT2; sirtuin 2; sirtuin type 2; sirtuin-2
• Host Species: Rat
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 22933
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid