Tocris™ SIS3

Selective Smad3 inhibitor; inhibits TGF-betaR1 signaling

Manufacturer: Tocris™ 5291/50

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Catalog No. 52-915-0

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Disclaimers:

For Research Use Only


    Specifications

    Description SIS3
    Molecular Weight 489.99
    Purity >98
    Quantity 50mg
    Product Type SIS3

    Selective Smad3 inhibitor; attenuates TGF-β1-dependent Smad3 phosphorylation and DNA binding. Has no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. Inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts. Also inhibits TGF-β2-induced endothelial cell differentiation in iPSCs.

    • Chemical Name: 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline hydrochloride
    • Formula: C28H27N3O3.HCl
    • CAS Number: 521984-48-5
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >98

  • Description & Specifications

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