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SIX5 Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 229381AP

Catalog No. 50-173-3968


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Description

Description

Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP (DM locus-associated homeodomain protein), is a transcription factor that is expressed in various structures of the adult eye. Localized to the cytoplasm in early development and to the nucleus in the later stages of development,Six5 is involved in regulation of organogenesis and in maintece of retinal formation. Six5 is able to bind the 5 ft.-TCA[AG][AG]TTNC-3 ft. DNA sequence found in the myogenin and IGFBP5 promoters and, through this binding, can control transcription of the associated mRNA. Six5 is regulated via association with DACH1 (dachshund homolog 1) and is co-activated by the EYA (eyes absent) proteins. Defects in the gene encoding Six5 are the cause of branchiooto- renal syndrome type 2 (BOR2), an autosomal disorder characterized by hearing loss, a deep overbite and myopia. Two isoforms exist due to alternative splicing events.
Specifications

Specifications

SIX5
0.47 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q8N196
BOR2, DMAHP, Homeobox protein SIX5, Sine oculis homeobox homolog 5, SIX homeobox 5, SIX5
Rabbit
IgG
150 μL
-20°C
Primary
147912
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
SIX5
Liquid
SIX5
SIX5 Fusion Protein Ag18993
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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