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SKI Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA551253

Catalog No. PA551253


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Description

Description

The antibody detects endogenous levels of total SKI protein.

TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
Specifications

Specifications

SKI
Polyclonal
Unconjugated
SKI
Liquid
SKI
Synthetic peptide of human SKI
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
2.8 mg/mL
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
P12755
SGS, SKV
Rabbit
IgG
100 μL
-20°C
Primary
6497
Documents
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