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SLC22A17 Mouse anti-Human, Clone: OTI2D6, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527266

Catalog No. PIMA527266


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Description

Description

The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins expressed predomitly in kidney and liver. Each contain 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways such as uniporters that mediate facilitated diffusion in either direction (OCTs), as anion exchangers (OAT1, OAT3 and URAT1), and as Na(+)/l-carnitine cotransporter (OCTN2). Slc22 family members participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart. Mutations in the Slc22 family may cause specific diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may change drug absorption or excretion. Recent studies show the expression of Slc22A17 as receptor for Lipocalin 2 is relatively high in hematopoietic stem cells.
Specifications

Specifications

SLC22A17
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q8WUG5
24p3R, BOCT, BOIT, NGALR, NGALR2, NGALR3, hBOIT; 24p3 receptor; NGAL receptor; brain-type organic cation transporter; lipocalin-2 receptor; neutrophil gelatinase-associated lipocalin receptor; potent brain type organic ion transporter; solute carrier family 22 (organic cation transporter), member 17; solute carrier family 22 member 17
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
51310
Immunohistochemistry (Paraffin), Western Blot
OTI2D6
Unconjugated
SLC22A17
Liquid
SLC22A17
Human recombit protein fragment corresponding to amino acids 241-300 of SLC22A17 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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