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SLUG Mouse anti-Human, Clone: OTI1G7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526394

Catalog No. PIMA526394


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Description

Description

Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.
Specifications

Specifications

SLUG
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O43623
SLUG, SLUGH1, SNAIL2, WS2D; neural crest transcription factor SLUG; protein snail homolog 2; slug (chicken homolog), zinc finger protein; zinc finger protein SNAI2
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
6591
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI1G7
Unconjugated
SNAI2
Liquid
SNAI2
Full length human recombit protein of SNAI2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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