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DIABLO Rabbit anti-Human, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer:  Invitrogen MA527979

Catalog No. PIMA527979


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Description

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using Recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of maligt disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms. Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).
Specifications

Specifications

DIABLO
Recombinant Monoclonal
Unconjugated
DIABLO
Liquid
Rabbit
IgG
100 μl
-20°C
Primary
56616
Immunohistochemistry, Western Blot
RM271
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Q9NR28
DIABLO
A peptide corresponding to the C-terminus of human Smac (Diablo homolog, mitochondrial)
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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