SMC1A Mouse anti-Human, Mouse, Clone: OTI1C5, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF809791
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCOStructural Maintece of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromo proteins are conserved in eukaryotes and lead to mitotic chromosome segregatior defects. This suggests a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. Mutations in the gene can lead to Cornelia de Lange syndrome 2.
|Human recombit protein fragment corresponding to amino acids 889-1016 of human SMC1A produced in E.coli.|
|PBS with 8% trehalose and no preservative; pH 7.3|
|CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB|
|-20° C, Avoid Freeze/Thaw Cycles|
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