SMN1/SMN2 Mouse anti-Human, Clone: 2B10, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527878
The synthetic peptide sequence is 22-52aa, RRGTGQSDDSDIWDDTALIKAYDKAVASFKH Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.The SMN1 gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein - survival motor neuron protein. The SMN complex plays a catalyst role in the assemble of small nuclear ribonucleoproteins, the building blocks of the spliceosome. Mutations in the SMN1 gene are known to cause spinal muscular atrophy 1/2.
|A synthetic peptide corresponding to a sequence at the N-terminus of human SMN1/2.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 4MG trehalose, 4MG trehalose and 0.05MG sodium azide, 0.05MG sodium azide|
|Survival motor neuron protein, Component of gems 1, Gemin-1, SMN1, SMN, SMNT, SMN2, SMNC|
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