SNAI2 Mouse anti-Human, Clone: OTI2H3, liquid, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene TA504898
DescriptionSlug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|SLUG, SLUGH, SLUGH1, SNAIL2, WS2D|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Western Blot|
|Full length human recombit protein of human SNAI2 produced in E.coli.|
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