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Snail1 Mouse anti-Human, Clone: 20C8, eBioscience™ Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: LIFE TECHNOLOGIES 14985980
Description
The MAb 20C8 recognizes human Snail1, a 29 kDa zinc finger transcription factor. Snail1 and Slug both belong to a family of transcription factors that are responsible for inducing epithelial to mesenchymal transition (EMT) during normal organ development and tumor progression. Snail1 expression is localized to both the cytoplasm and nucleus and functions as a transcriptional repressor of E-cadherin, claudins, occludin, and desmoplakin. During embryonic development, Snail1 is localized to the mesoderm, while in the adult, expression is inducible and is usually limited to activated fibroblasts and some mesenchymal cells. Overexpression of Snail1 has been found in carcinomas and fibrosarcomas and may be used as an early marker for EMT.
Snail1 Monoclonal antibody specifically detects Snail1 in Human samples. It is validated for ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western BlotSpecifications
| Snail1 | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| O95863 | |
| Mouse | |
| 25 μg | |
| Primary | |
| Human | |
| Liquid |
| ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| 20C8 | |
| Unconjugated | |
| Snai1 | |
| AI194338; dJ710H13.1; Protein sna; protein snail homolog 1; SLUGH2; Sna; Sna protein; Sna1; SNAH; snai; SNAI1; SNAIL; snail 1; snail 1 homolog; snail 1 zinc finger protein; snail 1, zinc finger protein; snail family transcriptional repressor 1; snail family zinc finger 1; snail homolog 1; SNAIL1; Zinc finger protein SNAI1 | |
| Affinity chromatography | |
| RUO | |
| 6615 | |
| Antibody | |
| IgG2a κ |
Safety and Handling
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