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Snail1 Mouse anti-Human, Clone: 20C8, eBioscience™ Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  LIFE TECHNOLOGIES 14985995

Encompass

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Catalog No. 14-985-995


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Description

Description

The MAb 20C8 recognizes human Snail1, a 29 kDa zinc finger transcription factor. Snail1 and Slug both belong to a family of transcription factors that are responsible for inducing epithelial to mesenchymal transition (EMT) during normal organ development and tumor progression. Snail1 expression is localized to both the cytoplasm and nucleus and functions as a transcriptional repressor of E-cadherin, claudins, occludin, and desmoplakin. During embryonic development, Snail1 is localized to the mesoderm, while in the adult, expression is inducible and is usually limited to activated fibroblasts and some mesenchymal cells. Overexpression of Snail1 has been found in carcinomas and fibrosarcomas and may be used as an early marker for EMT.

Snail1 Monoclonal antibody specifically detects Snail1 in Human samples. It is validated for ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Specifications

Specifications

Snail1
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
O95863
Mouse
10 mg
Primary
Human
Liquid
ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
20C8
Unconjugated
Snai1
AI194338; dJ710H13.1; Protein sna; protein snail homolog 1; SLUGH2; Sna; Sna protein; Sna1; SNAH; snai; SNAI1; SNAIL; snail 1; snail 1 homolog; snail 1 zinc finger protein; snail 1, zinc finger protein; snail family transcriptional repressor 1; snail family zinc finger 1; snail homolog 1; SNAIL1; Zinc finger protein SNAI1
Affinity chromatography
RUO
6615
Antibody
IgG2a κ
Safety and Handling

Safety and Handling

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