SnoN Mouse anti-Canine, Human, Mouse, Non-human primate, Rat, Clone: OTI2F6, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526386
DescriptionPrincipal Names: SnoN; SNO; SKI-like; Ski-related Oncogene; SnoA; SKIL Official Gene Symbol- SKIL Gen Bank Accession Number- NP_005405 Gene ID- 6498(Human) 20482 (mouse)Gene Map Locus- 3q26 (human) SnoN, an 80 KDa protein, is a member of ski family of nuclear proto-oncogenes involved in regulation of cellular transformation and differentiation. Primarily expressed in two isoforms, SnoN is localized in cytoplasm in normal tissues and non-tumorigenic primary epithelial cells. In cancer tissues or cells, SnoN is exclusively localized in the nucleus. It plays a vital role in inhibition of cell cycle arrest induced by TGF-beta. Upon morphological differentiation or cell-cycle arrest, SnoN translocates into the nucleus, binds to Smad2, Smad3, and Smad4 on TGF-beta-responsive promoters and represses their ability to activate expression of TGF- target genes. It has also been found to mediate transcriptional repression of thyroid hormone receptor, Mad and pRb. Increased expression of SnoN has been detected in many human tumor cell lines suggesting a clinical significance.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|SNO, SnoA, SnoI, SnoN; ski-like protein; ski-related oncogene snoN|
|-20° C, Avoid Freeze/Thaw Cycles|
|114208, 20482, 488159, 6498, 696680|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 307-684 of SKIL produced in E.coli|
|Canine, Human, Mouse, Non-human primate, Rat|
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