Sorbitol Dehydrogenase Mouse anti-Human, Clone: OTI9E7, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524995
DescriptionSorbitol Dehydrogenase, also known as L-iditol 2-dehydrogenase, SORD or SORD1, is a 357 amino acid member of the zinc-containing alcohol dehydrogenase family. Widely expressed with highest expression in kidney and in the lens of the eye, Sorbitol Dehydrogenase enzymatically catalyzes the zinc-dependent interconversion of polyols, such as such as sorbitol and xylitol, to their respective ketoses. These reactions require NAD+ as an oxidizing agent and, together with Aldose Reductase, they comprise the sorbitol pathway that is involved in sugar production. Sorbitol Dehydrogenase deficiency leads to defects in this pathway and a subsequent accumulation of sorbitol within the cell, a condition that may be associated with diabetic complications such as cataracts and microvascular problems.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|SORD 1, SORD, SORD1, Sorbitol dehydrogenase|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot|
|Full length human recombit protein of SORD produced in HEK293T cell|
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