SOX10 Mouse anti-Human, Mouse, Allophycocyanin/Cy7, Clone: SOX10/991, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP259621APCCY7
DescriptionSOX10 Monoclonal antibody specifically detects SOX10 in Human, Mouse samples. It is validated for Flow Cytometry.
|Recombinant human SOX10 protein fragment (around aa115-269) (exact sequence is proprietar|
|Protein A or G purified|
|Store at 4°C in the dark. Do not freeze.|
|The specificity of this monoclonal antibody to human, mouse SOX10 was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of ∽55kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG -box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells|
|PBS with 0.05% Sodium Azide|
|MGC15649, PCWH, SRY (sex determining region Y)-box 10, SRY-related HMG-box gene 10, transcription factor SOX-10, WS4C, WS4mouse, human homolog of|
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