SOX17 Mouse anti-Canine, Human, Clone: OTI2G8, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524891
DescriptionSOX17 (transcription factor SOX-17) belongs to the SRY-related HMB box family of transcription factors. It acts as a transcription regulator that binds target promoter DNA and bends the DNA. It binds to the sequences 5 ft.-AACAAT- ft.3 or 5 ft.-AACAAAG-3 ft.. SOX17 modulates transcriptional regulation via WNT3A and inhibits Wnt signaling. It promotes degradation of activated CTNNB1. SOX17 plays an essential role in the regulation of embryonic development and is required for normal looping of the embryonic hear tube and for normal development of the definitive gut endoderm. Mutations in the gene can result in vesicoureteral reflux.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|VUR3, SRY-related HMG-box transcription factor SOX17, transcription factor SOX-17|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 177-414 of SOX17 produced in E.coli|
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