SOX2 Monoclonal Antibody (20G5), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA1014

Catalog No. PIMA1014

Description

Western blot analysis of MA1-014 specifically detects SOX2 protein at ∽36 kDa in the nucleus of human and mouse embryonal carcinoma and iPS cells.

SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of the SOX2 gene is required for stem-cell maintece in the central nervous system, and also regulates gene expression in the stomach. The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia.

Specifications

• Antigen: SOX2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA, 30% glycerol and 0.05% sodium azide
• Gene Accession No.: P48431, P48432
• Gene Symbols: SOX2
• Immunogen: Full-length human recombit protein expressed in bacteria
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Canine, Fish, Human, Mouse
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: ChIP assay, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: 20G5
• Conjugate: Unconjugated
• Gene: SOX2
• Gene Alias: ANOP3, MCOPS3, SRY-related HMG-box gene 2, transcription factor SOX-2, transcription factor SOX2, sex determining region Y box 2
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 20674, 488092, 6657
• Content And Storage: -20°C
• Form: Liquid