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SOX2 Rat anti-Human, Mouse, Clone: Btjce, eBioscience™ Invitrogen™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

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Catalog No. 14-981-137


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Description

Description

The Btjce MAb reacts with the transcription factor Sox2, a member of the SOX (sex determining region Y -related HMG (High Mobility Group) Box) family of proteins. Sox family members play a role in early organ development, and in particular, Sox2 is essential for regulating genes that control normal mammalian embryogenesis. Sox2 and family member Sox3 are expressed as early as the preimplantation and epiblast stages respectively. Later expression is restricted to the neuroepithelium. Sox2 has been shown to be necessary for maintaining self-renewal and pluripotency of mouse and human embryonic stem (ES) cells (ESC). Oct4 (POU5F1), Klf4, c-myc, and Sox2 were the original four factors used to reprogram differentiated mouse and human cells to induced pluripotent stem cells (iPSC). Expression of Sox2 is tightly regulated and recent studies have demonstrated that small changes in the levels of Sox2 in ES cells can trigger differentiation into multiple cell types. Sox2 expression is not limited to ES cells, it is also essential for early neurogenesis where its expression becomes restricted to the neural plate, and later to neural stem cells where it functions to suppress neural differentiation. Sox2 in combination with other stem cell markers can be used to characterize stem cell populations. Ectopic expression of Sox2 has been associated with multiple cancer types including colorectal and breast.

SOX2 Monoclonal antibody specifically detects SOX2 in Human, Mouse samples. It is validated for ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Specifications

Specifications

SOX2
ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Btjce
Unconjugated
SOX2
ANOP3; cb236; lcc; MCOPS3; RGD1565646; sex determining region Y-box 2; SOX 2; sox2; Sox-2; soxp; SRY (sex determining region Y)-box 2; SRY box 2; SRY-box 2; SRY-box 2; SOX2; SRY-box containing gene 2; SRY-box transcription factor 2; SRY-related HMG-box gene 2; transcription factor SOX2; transcription factor Sox-2; wu:fb83g04; wu:fc14d07; ysb; zgc:65860; zgc:77389
IgG2a, kappa
2 mg
4° C
Primary
20674, 6657
Liquid
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P48431, P48432
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Human, Mouse
SDS
Documents
Product Certifications
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