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Tocris Bioscience™ SP 100030 Available on GSA/VA Contract for Federal Government customers only.

NF-κB and AP-1 dual inhibitor

$206.00 - $831.50

Specifications

Chemical Name or Material N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide
Molecular Formula C14H5ClF9N3O
CAS 154563-54-9
Product Type Target: NFkB/IkB Inhibitors
Formula Weight 437.65
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
53-095-0 View Documents Tocris Bioscience™
5309/50
50mg Each for $831.50
Add to cart
 
53-091-0 Available on GSA/VA Contract for Federal Government customers only. View Documents Tocris Bioscience™
5309/10
10mg Each for $206.00
Add to cart
 
Description

Description

Potent dual inhibitor of NF-κB and AP-1 transcriptional activity (IC50 = 50 nM). Blocks production of IL-2, IL-8 and TNF-α from Jurkat T cells. Inhibits cytokine production selectively in T cells; exhibits minimal inhibition of cytokine production in other cell types. Decreases arthritic severity in a mouse model of collagen-induced arthritis. Also ameliorates muscle wasting in a rat model of cancer cachexia.

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Specifications

Specifications

N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide
154563-54-9
437.65
C14H5ClF9N3O
Target: NFkB/IkB Inhibitors
Safety and Handling

Safety and Handling

Recommended Storage : Store at 4°C

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