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SP1 Mouse anti-Human, Clone: GT2574, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527783

Catalog No. PIMA527783


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Description

Description

Positive Control: THP-1 Predicted Reactivity: Mouse (96%), Rat (99%), Rhesus Monkey (99%), Bovine (98%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.
Specifications

Specifications

SP1
Monoclonal
1 mg/ml
PBS with no preservative
P08047
SP1, Sp1 transcription factor
Mouse
IgG2a
100 μl
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
6667
Immunocytochemistry, Immunofluorescence, Western Blot
GT2574
Unconjugated
SP1
Liquid
SP1
Recombit protein encompassing a sequence within the center region of human SP1. The exact sequence is proprietary.
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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