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SPAG1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549729

Catalog No. PA549729


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Description

Description

The antibody detects endogenous level of total SPAG1 protein.

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombit human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombit polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.
Specifications

Specifications

SPAG1
Polyclonal
Unconjugated
SPAG1
Liquid
SPAG1
Synthetic peptide corresponding to a region derived from 760-774 amino acids of Human sperm associated antigen 1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
ELISA, Immunohistochemistry (Paraffin), Western Blot
0.9 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q07617
Sperm associated antigen 1, SP75, TPIS, HSD-3.8
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
6674
Documents
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