SPAG5 Mouse anti-Human, Clone: OTI2F2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527301
DescriptionSPAG5 (sperm associated antigen 5), also known as MAP126, hMAP126, DEEPEST or Astrin, is a 1,193 amino acid protein that is expressed at high levels in testis and at lower levels in liver, placenta, pancreas, colon and thymus. Localized specifically to spindle poles during prophase and throughout the spindle during metaphase and anaphase, SPAG5 is essential for proper spindle formation and is thought to be involved in the dynamic and functional regulation of mitotic spindles. Additionally, SPAG5 plays a role in sister chromatid cohesion and subsequent chromatid separation and, via its association with chromatids, is an important regulator of chromosome integrity. SPAG5 has a long stalk and a globular head domain through which if forms a homodimer that is characterized by aster-like structures. Upon DNA damage, SPAG5 may be phosphorylated by ATR or ATM.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Sperm-associated antigen 5; Astrin; Deepest; Mitotic spindle-associated protein p126; MAP126; SPAG5|
|-20° C, Avoid Freeze/Thaw Cycles|
|Human recombit protein fragment corresponding to amino acids 1-297 of SPAG5 produced in E.coli|
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