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SPAG5 Mouse anti-Human, Clone: OTI6G2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527302

Catalog No. PIMA527302


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Description

Description

SPAG5 (sperm associated antigen 5), also known as MAP126, hMAP126, DEEPEST or Astrin, is a 1,193 amino acid protein that is expressed at high levels in testis and at lower levels in liver, placenta, pancreas, colon and thymus. Localized specifically to spindle poles during prophase and throughout the spindle during metaphase and anaphase, SPAG5 is essential for proper spindle formation and is thought to be involved in the dynamic and functional regulation of mitotic spindles. Additionally, SPAG5 plays a role in sister chromatid cohesion and subsequent chromatid separation and, via its association with chromatids, is an important regulator of chromosome integrity. SPAG5 has a long stalk and a globular head domain through which if forms a homodimer that is characterized by aster-like structures. Upon DNA damage, SPAG5 may be phosphorylated by ATR or ATM.
Specifications

Specifications

SPAG5
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q96R06
Sperm-associated antigen 5; Astrin; Deepest; Mitotic spindle-associated protein p126; MAP126; SPAG5
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
10615
Western Blot
OTI6G2
Unconjugated
SPAG5
Liquid
SPAG5
Human recombit protein fragment corresponding to amino acids 1-297 of SPAG5 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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