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SPANXB1 Mouse anti-Human, Clone: OTI1E11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527454

Catalog No. PIMA527454


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Description

Description

Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-tail orientation with SPANX family member B2, which appears to be a duplication of the B1 locus. The SPANXB genes are unique members of this gene family, since they contain an additional 18 nt in their coding region compared to the majority of family members. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis.
Specifications

Specifications

SPANXB1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9NS25
SPANX family member B1, B1, CT11.2, SPANX-B, SPANXB
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
728695
Immunohistochemistry (Paraffin), Western Blot
OTI1E11
Unconjugated
SPANXB1
Liquid
SPANXB1
Full length human recombit protein of SPANXB1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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