Tocris™ Spautin 1

USP10 and USP13 inhibitor; inhibits autophagy

Manufacturer: Tocris™ 5197/10

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Catalog No. 51-971-0

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Disclaimers:

For Research Use Only


    Specifications

    Product Type Spautin 1
    Inhibitors Spautin 1
    Purity >98
    Molecular Weight 271.26
    Quantity 10mg

    Inhibitor of autophagy; inhibits USP10 and USP13 activity (IC50 values are 0.6 and 0.7µM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. Selectively promotes apoptosis of cancer cells under starvation conditions. Prevents the PDGF-induced conversion from the contractile to synthetic phenotype in vascular smooth muscle cells.

    • Chemical Name: 6-Fluoro-N-[(4-Fluorophenyl)methyl]-4-quinazolinamine
    • Formula: C15H11F2N3
    • CAS Number: 1262888-28-7
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >98

  • Description & Specifications

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