Tocris Spautin 1
USP10 and USP13 inhibitor; inhibits autophagy
Manufacturer: Tocris 5197/10
DescriptionInhibitor of autophagy; inhibits USP10 and USP13 activity (IC50 values are 0.6 and 0.7µM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. Selectively promotes apoptosis of cancer cells under starvation conditions. Prevents the PDGF-induced conversion from the contractile to synthetic phenotype in vascular smooth muscle cells.
- Chemical Name: 6-Fluoro-N-[(4-Fluorophenyl)methyl]-4-quinazolinamine
- Formula: C15H11F2N3
- CAS Number: 1262888-28-7
- Solubility: Soluble to 100mM in DMSO
- Purity: >98
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