SPDYA Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA116959

Catalog No. 01-950-188

Description

PA1-16959 is specific for the ∽36 kDa Speedy/Ringo protein (isoform 2). After a longer exposure, a 31 kDa band can be detected (isoform 1). There is also a non-specific band detected at ∽58 kDa.Suggested positive control: mouse testis lysate, mouse testis protein.

Speedy A, also known as SPDYA, SPDY1, Ringo3 or SPY1, is a 313 amino acid protein that localizes to the nucleus and belongs to the speedy/ringo family. Expressed at high levels in testis and at lower levels in brain, kidney, heart, bone marrow, colon, lung, liver spleen and placenta, Speedy A functions to regulate the G1/S phase transition of the cell cycle, specifically by binding to and activating Cdc2 p34, Cdk2 and p27. Additionally, Speedy A mediates cell survival during DNA damage, suggesting that Speedy A plays a role in proper cell cycle progression throughout the life of the cell. Multiple isoforms of Speedy A exist due to alternative splicing events. The gene encoding Speedy A maps to human chromosome 2, which encodes over 1,400 genes and comprises nearly 8% of the human genome.

Specifications

• Antigen: SPDYA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPDYA
• Gene Alias: 4921517J08Rik; 4930548B21Rik; Gs4; hSpy/Ringo A; Lm23; MLZ-465; mSpy/Ringo A; protein expressed in male leptotene and zygotene spermatocytes 465; Rapid inducer of G2/M progression in oocytes A; RINGO A; RINGO3; RINGOA; SPDY1; SPDYA; spdya {ECO:0000250; speedy A; speedy A1; speedy A2; speedy homolog 1; speedy homolog A; speedy homolog A (Xenopus laevis); speedy protein A; speedy/ringo; speedy/RINGO cell cycle regulator family member A; Speedy-1; spermatogenesis related protein Gs4; spy1; UniProtKB:Q5MJ70}
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 101123454, 192209, 245711, 70891
• Content And Storage: 4° C, do not freeze
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.1 mg/mL
• Formulation: tris citrate, tris phosphate with 0.1% sodium azide; pH 7-8
• Gene Accession No.: Q5IBH7, Q5MJ70, Q8R496
• Gene Symbols: SPDYA
• Immunogen: Synthetic peptide corresponding to residues 200-286 of human Speedy/Ringo.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Ovine, Rat
• Product Type: Antibody
• Isotype: IgG