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SPIB Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 157681AP

Catalog No. 50-173-0462


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Description

Description

Spi-B is a transcription factor belonging to a subfamily of ETS transcription factors with a conserved ETS domain that mediates specific DNA binding. Spi-B may form homotypic interactions and is known to interact with IRF4, CREBBP, EP300, SPI1/PU.1 related, JUN and TBP. As a sequence specific transcriptional activator it binds to the PU-box, a purine-rich DNA sequence (5 ft.-GAGGAA-3 ft.) that can act as a lymphoid-specific enhancer. Two isoforms of Spi-B are reported. Spi-B is usually expressed in plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells and promotes their development and block viral replication. Spi-B is not expressed in T-cells or granulocytes but may be present in stem cell populations of the liver and B-cells where it helps in B-cell receptor (BCR) signaling, normal B-cell development and antigenic stimulation.
Specifications

Specifications

SPIB
0.25 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O35906, Q01892, Q5EBA3
SPI B, SPIB, Transcription factor Spi B
Rabbit
IgG
150 μL
-20°C
Primary
272382, 499146, 6689
Immunoprecipitation, Western Blot
Unconjugated
SPIB
Liquid
Spib
SPIB Fusion Protein Ag8404
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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