SPIB Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 157681AP
DescriptionSpi-B is a transcription factor belonging to a subfamily of ETS transcription factors with a conserved ETS domain that mediates specific DNA binding. Spi-B may form homotypic interactions and is known to interact with IRF4, CREBBP, EP300, SPI1/PU.1 related, JUN and TBP. As a sequence specific transcriptional activator it binds to the PU-box, a purine-rich DNA sequence (5 ft.-GAGGAA-3 ft.) that can act as a lymphoid-specific enhancer. Two isoforms of Spi-B are reported. Spi-B is usually expressed in plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells and promotes their development and block viral replication. Spi-B is not expressed in T-cells or granulocytes but may be present in stem cell populations of the liver and B-cells where it helps in B-cell receptor (BCR) signaling, normal B-cell development and antigenic stimulation.
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|O35906, Q01892, Q5EBA3|
|SPI B, SPIB, Transcription factor Spi B|
|272382, 499146, 6689|
|Immunoprecipitation, Western Blot|
|SPIB Fusion Protein Ag8404|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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