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SPRTN Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA5107278

Catalog No. PIPA5107278


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Description

Description

Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 92%; Pig: 100%; Rabbit: 92%; Rat: 100%

SPRTN is a regulator of UV-induced DNA damage response: acts as a  ft.reader ft. of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.
Specifications

Specifications

SPRTN
Polyclonal
Unconjugated
SPRTN
Liquid
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
83932
Western Blot
0.5 mg/mL
PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
Q9H040
SPRTN
Synthetic peptide located within the following region: ATNREPSAHD YWWAEHQKTC GGTYIKIKEP ENYSKKGKGK AKLGKEPVLA
Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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