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SPRY1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA562392

Catalog No. PIPA562392


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Description

Description

Immunogen sequence: PRTAPRQEKH ERTHEIIPIN VNNNYEHRHT SHLGHAVLPS NARGPILSRS TSTGSAASSG SNSSASSEQG LLGRSPP Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 74%.

Sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. Four mammalian Sprouty homologues (Sprouty-1-4) have been identified. One study showed that overexpressed Sprouty-1 and -2 inhibits fibroblast growth factor and vascular endothelial growth factor-induced proliferation and differentiation by repressing pathways leading to MAP kinase activation. Sprouty proteins are also endogenous inhibitors of the Ras/MAP kinase pathway that play an important role in the remodeling of branching tissues, such as in development of the lung, kidney tubules, vascular system, and breast ducts. A recent study shows that Sprouty-1 and -2 may have tumor suppressing activity in the breast, and found that both proteins are consistently down-regulated in breast carcinomas.
Specifications

Specifications

SPRY1
Polyclonal
Unconjugated
SPRY1
Liquid
SPRY1
Recombit protein corresponding to Human SPRY1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry
0.2 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
O43609
SPRY1; hSPRY1; sprouty homolog 1, antagonist of FGF signaling (Drosophila); sprouty (Drosophila) homolog 1 (antagonist of FGF signaling); sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling)
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
10252
Documents
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