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SPT3 Mouse anti-Human, Clone: OTI3D1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526938

Catalog No. PIMA526938


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Description

Description

The transcription of many RNA polymerase II-dependent genes requires Spt3, a member of the S. cerevisiae SAGA complex. Transcription from delta sequences, the long terminal repeats that flank yeast Ty elements, requires the yeast SPT3 gene. Spt3 and Spt20 work together to recruit TATA-box binding protein (TBP) to the core promoter allowing TBP to bind to SAGA-dependent promoters. Null mutations in the Spt3 gene cause defects in sporulation, diploid filamentous growth, and haploid invasive growth, indicating that Spt3 has an important role in both mating and development pathways in yeast. At the promoters of some genes including yeast HO, HIS3 and TRP3 genes, Spt3 inhibits binding of TBP, resulting in reduced transcription. This repressive effect of Spt3 can be overcome by another member of the SAGA complex, GCN5, which promotes the formation of a TBP/TFIIA complex by histone acetylation.
Specifications

Specifications

SPT3
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O75486
Transcription initiation protein SPT3 homolog, SPT3-like protein, SUPT3H
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8464
Immunohistochemistry (Paraffin), Western Blot
OTI3D1
Unconjugated
SUPT3H
Liquid
SUPT3H
Full length human recombit protein of SUPT3H produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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