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SPTLC1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA551091

Catalog No. PA551091


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Description

Description

SPTLC1 Polyclonal Antibody detects endogenous levels of SPTLC1 protein.

Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5 ft.-phosphate as a cofactor. SPT1 is the long chain base subunit 1 of mammalian serine palmitoyltransferase. SPT1 is not catalytically active but is necessary for the stabilization of the SPT2 subunit and anchoring the holoenzyme to the cytosolic face of the endoplasmic reticulum. Missense mutations in this gene have been identified in patients with hereditary sensory neuropathy type 1 (HSAN1). These mutations induce a shift in the substrate specificity of the holoenzyme, leading to the formation and accumulation of two neurotoxic sphingolipids.
Specifications

Specifications

SPTLC1
Polyclonal
Unconjugated
SPTLC1
Liquid
SPTLC1
Synthesized peptide derived from the C-terminal region of human SPTLC1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
ELISA, Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
O15269, O35704
SPTLC1, LCB1, Serine palmitoyltransferase 1, Long chain base biosynthesis protein 1, LCB 1, Serine-palmitoyl-CoA transferase 1, SPT 1, SPT1
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
10558, 268656, 361213
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