Tocris SR 48692
Selective non-peptide NTS1 antagonist
Manufacturer: Tocris 3721/10
DescriptionNeurotensin antagonist; selective for NTS1 over NTS2 (apparent affinity, Ke, is 36nM for NTS1). Competitively inhibits binding of [125I]-neurotensin to HT29 and N1E115 cell membranes (IC50 values are 15.3 and 20.4nM respectively). Orally bioavailable.
- Chemical Name: 2-[[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[188.8.131.52,7]decane-2-carboxylic acid
- Formula: C32H31ClN4O5
- CAS Number: 146362-70-1
- Solubility: Soluble to 20mM in DMSO
- Purity: >98
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