Invitrogen™ SR-BI/SR-BII Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA132415

Catalog No. PA132415

Description

The PA1-32415 immunogen is: Synthetic peptide from the extracellular domain (residues 230-380) of Scavenger Receptor-BI/BII was expressed as two tandem copies in bacteria using the pET system. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.

Specifications

• Antigen: SR-BI/SR-BII
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SCARB2
• Gene Alias: 85 kDa lysosomal membrane sialoglycoprotein; 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2; 9330185J12Rik; AI120173; AMRF; CD36; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II); CD36 antigen-like 1; CD36 antigen-like 2; CD36L1; CD36L2; Cla1; CLA-1; Collagen type I receptor, thrombospondin receptor-like 1; D5Ertd460e; EPM4; HDL QTL 1; Hdlq1; HDLQTL6; Hlb398; HLGP85; LGP85; LIMP II; LIMP2; LIMP-2; LIMPII; lysosome membrane protein 2; Lysosome membrane protein II; MLGP85; mSR-BI; Scarb1; Scarb2; scavanger receptor class B type 1; scavenger receptor b1; scavenger receptor class B member 1; Scavenger receptor class B member 2; scavenger receptor class B type I; scavenger receptor class B type III; scavenger receptor class B, member 1; scavenger receptor class B, member 2; scavenger receptor class B1; SRB1; SR-B1; SR-B1/B2; SRBI; SR-BI; SR-BI/BII; SR-BII
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: Conc. Not Determined
• Formulation: Whole serum with 0.02% sodium azide
• Gene Accession No.: O35114, P27615, P97943, Q14108, Q61009, Q8WTV0
• Gene Symbols: SCARB1, SCARB2
• Immunogen: Synthetic peptide from the extracellular domain (residues 230-380) of Scavenger Receptor-BI/BII was expressed as two tandem copies in bacteria using the pET system.
• Regulatory Status: RUO
• Gene ID (Entrez): 117106, 12492, 20778, 25073, 949, 950
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid