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Thermo Scientific™ Lab Vision™ SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1, Mouse Monoclonal Antibody .

$191.00 - $744.00

Specifications

Antigen SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1
Clone 2A4
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Conjugate Unconjugated
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Products 5
Catalog Number Mfr. No. Concentration Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Concentration Quantity Price Quantity & Availability  
MS1207P
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Thermo Scientific™
MS1207P
200μg/mL 1mL Each for $697.50
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MS1207P0
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Thermo Scientific™
MS1207P0
200μg/mL 100μL Each for $191.00
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MS1207P1
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Thermo Scientific™
MS1207P1
200μg/mL 500μL Each for $580.00
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MS1207P1ABX
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Thermo Scientific™
MS1207P1ABX
1mg/mL 100μL Each for $523.00
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MS1207PABX
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Thermo Scientific™
MS1207PABX
1mg/mL 200μL Each for $744.00
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Description

Description

Provide accurate, reproducible results with the Thermo Scientific™ SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1, Mouse Monoclonal Antibody .

SREBP-1 and -2 are transcription factors which participate in the control of cholesterol homeostasis. SREBPs proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to conditions of low cellular sterol. Upon activation of SREBP-1 or -2, an ~480-500 amino acid, N-terminal cleavage fragment of these proteins enters the nucleus and activates transcription of enzymes and other proteins required for cholesterol synthesis. SCA (SREBP-cleavage activity) and caspase-3 proteases cleave SREBPs. SREBP proteins containing point mutations at caspase-3 cleavage sites (Asp460 in SREBP-1 and Asp468 in SREBP-2) do not become cleaved following induction of apoptosis, suggesting that SREBPs may play some role in apoptotic processes.

Host Species: Mouse

Clone: 2A4

Isotype: IgG1/κ

Species Reactivity: Human and Hamster. Others not known.

Epitope: aa 301-407

Immunogen: Recombinant protein encoding N-terminal amino acids 301-407 (the bHLH/leucine zipper domain) of human SREBP-1

Molecular Weight: 125kDa (precursor) and 60-70kDa (cleaved)

Positive Control: HeLa and IMR5 cells

Cellular Localization: Cytoplasmic and nuclear

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Not verified)

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1
Immunoprecipitation, Western Blot
Unconjugated
Murine
Transcription Regulation
Recombinant protein encoding N-terminal amino acids 301-407 (the bHLH/leucine zipper domain) of human SREBP-1
2A4
Monoclonal
Concentrated
RUO
Primary
IgG2a kappa
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